Characterization of a novel transcriptional feedback loop regulating lipid metabolism

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cthrc1, a Novel Circulating Hormone Regulating Metabolism

BACKGROUND We discovered the gene Collagen Triple Helix Repeat Containing 1 (Cthrc1) and reported its developmental expression and induction in adventitial cells of injured arteries and dermal cells of skin wounds. The role of Cthrc1 in normal adult tissues has not yet been determined. METHODOLOGY/PRINCIPAL FINDINGS We generated mutant mice with a novel Cthrc1 null allele by homologues recomb...

متن کامل

MicroRNAs regulating lipid metabolism in atherogenesis.

MicroRNAs have emerged as important post-transcriptional regulators of lipid metabolism, and represent a new class of targets for therapeutic intervention. Recently, microRNA-33a and b (miR-33a/b) were discovered as key regulators of metabolic programs including cholesterol and fatty acid homeostasis. These intronic microRNAs are embedded in the sterol response element binding protein genes, S...

متن کامل

A new role of p53 in regulating lipid metabolism.

Dear Editor, The p53 tumor suppressor maintains the normal cell growth and genomic stability by launching cell cycle arrest, DNA repair, or apoptosis in response to DNA damage or other forms of cellular stress. Recent studies also suggest that p53 is capable of much broader cellular functions, including the regulation of energy metabolism and autophagy. However, the role of p53 in regulating li...

متن کامل

ANGPLT3: A novel modulator of lipid metabolism

Angiopoietin-like proteins (ANGPTLs) have emerged as an important regulator of lipid and glucose metabolism as well as insulin sensitivity. ANGPTL3 plays a key role in regulating circulating triglycerides (TG) and cholesterol levels through reversible inhibition of lipoprotein lipase (LPL) and endothelial lipase enzymes activity. Loss of function mutation of ANGPTL3 gene has been identified in ...

متن کامل

RpoS-dependent transcriptional control of sprE: regulatory feedback loop.

The stationary-phase response exhibited by Escherichia coli upon nutrient starvation is mainly induced by a decrease of the ClpXP-dependent degradation of the alternate primary sigma factor RpoS. Although it is known that the specific regulation of this proteolysis is exercised by the orphan response regulator SprE, it remains unclear how SprE's activity is regulated in vivo. Previous studies h...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The FASEB Journal

سال: 2010

ISSN: 0892-6638,1530-6860

DOI: 10.1096/fasebj.24.1_supplement.lb114